The Importance of Dose-Time-Response Relationships for Hazard Identification and Limitation of Animal Experiments
Historian Heiko Stoff has recently sketched a fascinating controversy in the 1950’s on chemical risk assessment. Two renowned scientists in the Farbstoffkommission (Dye Committee) of the Deutsche Forschungsgemeinschaft (DFG, German Research Community), pharmacologist Hermann Druckrey and biochemist (and Nobel Prize winner) Adolf Butenandt, were advocates of a preventive risk approach. Only substances with a reversible mechanism of action and dose-dependent toxicology were acceptable in their eyes because safe exposure concentrations below a threshold of toxicity could be defined.